7DW8-5 is a glycolipid analog related to Alpha-Galcer which is an immunostimulate iNKT agonist upregulating cytokine production in human and mice. While majority of research with 7DW8-5 as a vaccine adjuvant the upregulated expression of cytokines may have cytoxic effects on tumors, infectious diseases and autoimmune disorders.
7DW8-5 chemical structure of 7DW8-5 is similar to Alpha-GalCer with the only difference with a shorter fatty acyl chain and florinated benzyme ring at end of fatty acyl chain.
7DW8-5 chemical structure
7DW8-5 chemical name:
7DW8-5 molecular formula: C41H72FNO9
7DW8-5 ppearance: White to off-white powder
Solubility: 7DW8-5 is insoluble in water, methanol or ethanol. 7DW8-5 is soluble in dimethyl sulfoxide (DMSO). The solution in phosphate buffered saline (PBS) with 10% Tween 20 or 80 remained clear at 4°C for 7 days. The solution in PBS with 5% Tween 80 remained clear at 4°C for 5 days. After more than 20 days at 4°C the samples became gel-like substance except the solution in PBS with 10% Tween 80 which remained clear solution with some floats.