KRN7000 research in Japan

Riken Institute research with Alpha-GalCer

SOCS3 in T and NKT cells negatively regulates cytokine production and ameliorates ConA-induced hepatitis

Alpha-GalCer ameliorates listeriosis by accelerating infiltration of Gr-1+ cells into the liver

Interleukin-2 gene transfer potentiates the alpha-galactosylceramide-stimulated antitumor effect by the induction of TRAIL in NKT and NK cells in mouse models of subcutaneous and metastatic carcinoma

Combination therapy of in vitro-expanded natural killer T cells and alpha-galactosylceramide-pulsed antigen-presenting cells in patients with recurrent head and neck carcinoma

Antitumor activity of alpha-galactosylceramide, KRN7000, in mice with the melanoma B16 hepatic metastasis and immunohistological study of tumor infiltrating cells

Role of alpha-galactosylceramide-activated Valpha14 natural killer T cells in the regulation of allergic diseases

Alpha-galactosylceramide promotes killing of Listeria monocytogenes within the macrophage phagosome through invariant NKT-cell activation

Murine induced pluripotent stem cells can be derived from and differentiate
into natural killer T cells

NKT 細胞免疫系を標的にした頭頚部癌の
免疫細胞治療の開発に関する研究

海洋天然物の新しい薬理活性 : 沖縄産海綿の生産するagelasphinを母化合物とするKRN7000の開発

A Phase I Study of Alpha-Galactosylceramide (KRN7000)–Pulsed Dendritic Cells in Patients with Advanced and Recurrent Non–Small Cell Lung Cancer

Activated liver dendritic cells generate strong acquired immunity in alpha-galactosylceramide treatment

Laboratory for Immune Regulation

Induction of Th1-biased cytokine production by Alpha-carba-GalCer, a neoglycolipid ligand for NKT cells

Natural killer T cells are involved in adipose tissues inflammation and glucose intolerance in diet-induced obese mice

Antitumor Effect of Alpha-Galactosylceramide (KRN7000) on Spontaneous Hepatic Metastases Requires Endogenous Interleukin 12 in the Liver

Severe loss of invariant NKT cells exhibiting anti-HTLV-1 activity in patients with HTLV-1-associated disorders

Activation of Valpha24NKT cells in malignant pleural effusion in patients with lung cancer

The Effects of Natural Killer T Cells on Atherosclerosis

Neutralization of tumor necrosis factor abrogates hepatic failure induced by alpha-galactosylceramide without attenuating its antitumor effect in aged mice

Expansion of Valpha24(+)Vbeta11(+) NKT cells from cord blood mononuclear cells using IL-15, IL-7 and Flt3-L depends on monocytes

Dendritic cell maturation by CD11c- T cells and Valpha24+ natural killer T-cell activation by alpha-galactosylceramide

KRN7000, a novel immunomodulator, and its antitumor activities

Alpha-glycosylceramides enhance the antitumor cytotoxicity of hepatic lymphocytes obtained from cancer patients by activating CD3-CD56+ NK cells in vitro

Antitumor activity of alpha-galactosylceramide, KRN7000, in mice with EL-4 hepatic metastasis and its cytokine production

Cross-presentation of glycolipid from tumor cells loaded with alpha-galactosylceramide leads to potent and long-lived T cell mediated immunity via dendritic cells

Identification of canine natural CD3-positive T cells expressing an invariant T-cell receptor alpha chain

Intrahepatic delivery of alpha-galactosylceramide-pulsed dendritic cells suppresses liver tumor

Natural killer T cell-mediated antitumor immune responses and their clinical applications

Therapeutic effect of alpha-galactosylceramide-loaded dendritic cells genetically engineered to express SLC/CCL21 along with tumor antigen against peritoneally disseminated tumor cells

Cutting Edge: Inhibition of Experimental Tumor Metastasis by Dendritic Cells Pulsed with Alpha-Galactosylceramide

Mechanism of NKT cell activation by intranasal coadministration of alpha-galactosylceramide, which can induce cross-protection against influenza viruses

Potent Anti-tumor effects of Combination therapy using Interleukin-23 and .ALPHA.-galactosylceramide